Study attempts to find new way to combat aggressive breast cancer
Mar 6, 2012
A new study conducted by researchers from the Max Planck Institute for Heart and Lung Research found a new way to attack aggressive breast cancer in mice, and their hope is to find the same result in humans.
The researchers targeted the receptor protein Plexin B1 and blocked it from interacting from the ErbB-2 protein, which is detected in tumor cells. Plexin B1 helps the ErbB-2 protein move around, thus metastasising the cancer. By blocking it, it lowers the chance of the cancer spreading while giving the patient a better prognosis.
"We concluded from this observation that it should be possible to prevent the formation of metastases by switching off Plexin-B1," said leader of the research Thomas Worzfeld. "We were able to establish a drastic reduction in the lung metastases in the animals without Plexin-B1. The effect could even be observed with the naked eye."
According to the American Cancer Society, breast cancer is the second leading cause of cancer-related death among women, following only lung cancer. However, the death rate has been decreasing since 1990 due to advancements in research and breakthrough breast cancer news.